Palonosetron might not attenuate spinal anesthesia-induced hypotension during orthopedic surgery
Anesthesia and Pain Medicine
;
: 195-200, 2016.
Article
in English
| WPRIM
| ID: wpr-52555
ABSTRACT
BACKGROUND:
5-Hydroxytryptamine3 (5-HT3) receptor antagonists have been reported to attenuate spinal anesthesia-induced hemodynamic changes. This study was conducted to determine whether the second generation 5-HT3, antagonist palonosetron attenuates hypotension and bradycardia during spinal anesthesia.METHODS:
Sixty adult patients scheduled for lower limb surgery were enrolled in this study. Patients were randomly assigned to receive either normal saline (Control group, N = 30) or palonosetron (0.075 mg, i.v.) (Palonosetron group, N = 30) prior to spinal anesthesia. Hemodynamic variables were recorded during anesthesia.RESULTS:
The mean blood pressure (MBP) were 89.2 ± 11.4 mmHg in the control group and 87.6 ± 12.1 mmHg in the palonosetron group at 10 min after intrathecal injection (P = 0.609). The median blocked levels of the control group and the palonosetron group were T10 (interquartile range, 9-10) and T10 (8-10) at 20 min after intrathecal injection (P = 0.939). Requirements for ephedrine, phenylephrine, and atropine were similar (P = 0.652, 0.533 and 0.417, respectively). The incidences of hypotension (40% vs. 41%) and bradycardia (7% vs. 17%) were comparable (P = 0.562, P = 0.198, respectively) between the control and the palonosetron group. There were no significances in the changes of systolic blood pressure, diastolic blood pressure, MBP and heart rate by the group (P = 0.632, 0.287, 0.556, 0.733, respectively).CONCLUSIONS:
Intravenous palonosetron (0.075 mg) prior to spinal anesthesia might not attenuate spinal anesthesia-induced hypotension during low level of neuroaxial block for lower limb surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthopedics
/
Phenylephrine
/
Atropine
/
Blood Pressure
/
Injections, Spinal
/
Bradycardia
/
Incidence
/
Lower Extremity
/
Ephedrine
/
Heart Rate
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Anesthesia and Pain Medicine
Year:
2016
Type:
Article
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