Study on Bioequiavailability in Human Body between Domestic and Imported Roxithromycin / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-525591
ABSTRACT
OBJECTIVE:
To study the bioequiavailability of domestic roxithromycin tablets and imported ones.METH?ODS20male healthy volunteers took single dose of150mg roxithromycin tablet orally in a random crossover design,blood concentrations were determined by LC-MS.RESULTS:
The main pharmacokinetic parameters of domestic and imported tablets were determined respectively as follows,AUC 0~72 were(72.81?23.85)(mg?n)/L and(72.63?20.86)(mg?h)/L,AUC 0~∞ were(74.41?24.45)(mg?h)/L and(74.42?24.45)(mg?h)/L,C max were(6.46?1.51)mg/L and(6.58?1.55)mg/L,t max were(1.9?0.5)h and(1.8?0.5)h,t 1/2 were(13.56?1.35)h and(14.18?1.50)h,the relative bioavailability of the homemade tablet to imported one was(99.8?11.2)%.CONCLUSIONS:
Domestic and imported roxithromycin are bioequivalent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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