Study on the Effect of Borneol Nasal Drops on the Vasopermeability of Nasal Mucosa and Cerebral Vessel of Guinea Pigs / 中国药房

ABSTRACT

OBJECTIVE:To observe the effect of different concentration of borneol nasal drops on the vasopermeability of nasal mucosa and the cerebral vessels.METHODS:Guinea pigs were divided into5groups,i.e.borneol group in3different concentrations(0.5%,1.0%and2.0%),histamine group and liquid paraffin group.Guinea pigs were injected i.v with2%evans blue(EB)after administration with nasal drops,which were then put to death10min later;the nasal mucosa and brain tissue of which were obtained and the EB contents in which were determined.RESULTS:Compared with the liquid paraffin group,the EB contents in the nasal mucosa and brain tissue in the borneol groups were higher(P