Determination of Betahistine in Human Plasma by RP-HPLC / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-525742
ABSTRACT
OBJECTIVE:
To establish RP-HPLC method for the determination of betahistine in human plasma.METHODS:
The separation of betahistine was performed on C18 column with a detection wavelength of 261nm.the mobile phase was composed of 0.05mol/L ammonium acetate-acetonitrile-0.3mol/L sodium lauryl sulphate (60∶40∶1.5)with a flow rate of 0.5ml/min.RESULTS:
The linear range of betahistine was 24~480ng/ml,the recovery rate was 81.75%~87.99%with the intra-day RSD at 0.60%~4.82%and inter-day RSD at 4.78%~12.15%.CONCLUSION:
This method developed in the present study is simple,fast,accurate and reproducible,which can be used as the pharmacokinetic study for betahistine in human body.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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