Effects of sodium metabisulfite on sodium current in acutely isolated rat hippocampal CA1 neurons / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-525762
ABSTRACT
AIM:
To study the effects of sodium metabisulfite (SMB), sulfur dioxide (SO_2) and its derivatives in vivo, sodium bisulfite and sulfite, on Na~+ currents. The effects of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) against SMB were also studied in freshly dissociated hippocampal CA1 neurons in rats.METHODS:
The whole-cell patch-clamp techniques were used in the experiments.RESULTS:
① SMB increased the voltage-activated Na~+ currents in a concentration-and voltage-dependent manner. The amplitudes of Na~+ currents was increased (22.36?3.28) % and (65.05?5.75)% (n=10) by SMB at 2 ?mol/L and 20 ?mol/L, respectively. ② SMB (10 ?mol/L) did not affect the activation process, but changed the inactivation process significantly. Before and after application of 10 ?mol/L SMB, the half-inactivation voltage was (-82.38)?0.54) mV and (-69.39)?0.41) mV (n=10, P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1999
Type:
Article
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