Neurokinin A and gene expression in lung of asthmatic guinea pigs exposed to chronic cigarette smoke / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1999.
Article
in Chinese
| WPRIM
| ID: wpr-525783
ABSTRACT
AIM:
To study the changes of neurokinin A (NKA) and NKA mRNA in lung tissues of asthmatic guinea pigs exposed to chronic cigarette smoke and investigate the mechanism.METHODS:
The model of asthma in guinea pigs was made by exposure to aerosolized ovalbumin and animals were randomly assigned into ① inhale cigarette smoke (ICS) 2 weeks before provoked; ② ICS 2 weeks after provoked; ③ 2 weeks after provoked (no-ICS); ④ asthma (no-ICS before provoked); ⑤ normal control. The contents of NKA in lung tissues were detected by ELISA and NKA mRNA expression was detected by reverse transcription-polymerase chain reaction.RESULTS:
① The levels of NKA and NKA mRNA expression in lung tissues of asthma group were significantly higher than those in normal control group (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1999
Type:
Article
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