Effects of endogenous nitric oxide on potassium channels of bronchial smooth muscle cells from asthmatic rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-525945
ABSTRACT
AIM:
To investigate the effects of in vivo application of L - arginine on potassium channels in bronchial smooth muscle cells (BSMC) isolated from asthmatic model rats.METHODS:
Male SD rats were randomly divided into control group,asdimatic group and asthmatic rats treated with L-arginine (L-Arg group). Single BSMCs were obtained by acute enzyme separation method. The resting membrane potential (Em), Ca2+ - activated K+ channels (BKca) currents and voltage - dependent K+ channel (Kv) currents in BSMCs were recorded under whole - cell patch clamp technique.RESULTS:
(1) The Em of asthmatic group was significantly lower than that in control group ( P 0.05) . (2) The peak current density at + 50 mV of Kca IKca in asthmatic group [ (43.8?16.5) pA/pF] was significandy lower than that in normal group [ (72.5?19.9) pA/pF] ( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2000
Type:
Article
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