Effects of Electrolytes on the Stablility of Total Parental Nutrient Solutions / 中国药房

ABSTRACT

OBJECTIVE:To investigate the effect of electrolytes on the stability of the total parenteral nutrient(TPN) solutions.METHODS:The pH values and number changes of solution microparticles of 4 groups of TPN sample solutions that of different electrolytes were determined at 0h after preparation and 4 hours,8hours,12hours,16hours and 24hours,respectively after storage under room temperature(20℃～22℃). And the appearances of which were observed under naked eyes. RESUL_ TSNo changes were noted as for the pH of 4 groups of solutions within 24h.For the numbers of microparticles(≥5?m),those in Group 4(to which group valence 1 and valence 2 electrolytes were added) showed a rapid increase to peak value from the very start;while those of the other groups increased with the extension of storage time.Stratification appeared in Group 3(to which group,valence 2 electrolytes had been added) and Group 4(to which group,valence 1 and valence 2 electrolytes were added) 6 hours after preparation.Curdling reaction was noted in Group 2(to which group,valence 1 electrolytes had been added) at 12th hour.Neither sediments nor stratification appeared in Group 1(no electrolytes were added to which group).CONCLUSION:El_ectrolytes have certain influences on the stability of the TPN solutions.Care should be taken to the dosage of which at preparation.Furthermore,once prepared,the solution should be infused as soon as possible and the storage of which should not beyond 24h.