Assaying of Principal Agent in Amikacin Sulfate Injection by Polarimetry / 中国药房

ABSTRACT

OBJECTIVE:To establish polarimetry for the assaying of the principal agent in amikacin sulfate injection. METHODS:The optical rotation of amikacin sulfate was determined with 1dm determination tube with water as solvent at a wavelength of 589.4nm.RESULTS:The linear range of amikacin was 1～20mg/ml(r=0.9 999);The average recovery rate was 99.8%(RSD=0.89%,n=5).CONCLUSION:The method is simple,fast and accurate,and it can be used for the quality control of amikacin sulfate injection.