Protective Effect of Probucol on Cerebral Microvascular Endothelial Cells Injury / 中国药房

ABSTRACT

OBJECTIVE:To observe the protective effect of homocysteine(Hcy)on rats’cerebral microvascular endothe?lial cells(RCMEC)injury.METHODS:RCMEC were divided into injury group and normal control group,the effect of Hcy on which was observed;Besides,RCMEC were divided into normal control group,injury group and probucol groups of different dosage,the lactate dehydrogenase(LDH)release rate and the cells growth curve in each group were observed.RESULTS:As compared with the normal control group,the growth of RCMEC in the injury group was inhibited and the release rate of LDH increased remarkably;The release rate of LDH decreased in turn when probucol was in a concentration range of10～50?mol/L.CONCLUSION:Hcy can cause toxic injury to RCMEC,probucol assumes dose dependent counteraction on Hcy-induced in?jury.