Influence of Compound Glycyrrhizin on Hepatic Fibrosis Indices and Cytokines in Patients with Chronic Hepatitis B / 中国药房

ABSTRACT

OBJECTIVE:To study the influence of compound glycyrrhizin on hepatic fibrosis indices and cytokines in patients with chronic hepatitis B(CHB).METHODS:84 patients with CHB were randomly divided into the treatment group(conventional liver protection+compound glycyrrhizin tablet) and control group(conventional liver protection).The serum levels of transforming growth factor-?1(TGF-?1),tumor necrosis factor-?(TNF-?),hyaluronic acid(HA),collagen type Ⅳ(C-Ⅳ) and laminin(LN) in those patients were measured by specific-ELISA and RIA before and after treatment.The serum levels in 20 healthy subjects were used as normal controls.RESULTS:The serum levels of HA,Ⅳ-C,LN,TGF-?1,TNF-? in patients with CHB were significantly higher than those in healthy subjects(P