In Vivo and in Vitro Antibacterial Action Study on Qinghou Buccal Tablets / 中国药房

ABSTRACT

OBJECTIVE: To study the antibacterial actions of Qinghou buccal tablets in vivo and in vitro. METHODS: Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of Qinghou buccal tablets were determined by standard test tube doubling dilution method;And the antibacterial action of which on staphylococcus aureus in mice in vivo were monitored. RESULTS: Qinghou buccal tablets had significant in vitro antibacterial action on staphylococcus aureus, ?-hemolytic streptococcus, ?-hemolytic streptococcus, streptococcus pneumoniae and hemophilus influenza, with MIC and MBC at 0.0 625～0.50g/ml and 0.125～1.0g/ml, respectively,and which had bacteriostatic action on mice that injected i.p. with staphylococcus aureus. CONCLUSION: Qinghou buccal tablets were proved to be of bacteriostatic actions in vitro and in vivo.