Evaluation of the expression of CD35 on red blood cells and CD11b on neutrophils in patients with chronic venous insufficiency / 中国普通外科杂志

ABSTRACT

Objective To investigate the expression of CD35 on red blood cells (RBC) and CD11b on neutrophils in patients with chronic venous insufficiency (CVI). Methods Anticoagulated peripheral venous blood was assayed by flow cytometry for CD35 expression on RBC and CD116 on neutrophils from 42 CVI patients in different clinical picture,etiology,anatomic distribution, pathophysiology (CEAP) and clinical classes, results were compared with that of eight normal control subjects. Result Circulating neutrophils were more reactive to CDllb in CVI C5-C6 patients. Higher expression of CD35 on RBC were observed in C4 patients. Conclusion CD35 on RBC and CDllb on neutrophils may participate in the pathogenesis and to an extent reflect the severeness of CVI.