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Effects of L-tetrahydropalmatine on hemeoxygenase-1 in cerebral tissue of rats and endogenous carbon monoxide during global cerebral ischemia/reperfusion / 中国中西医结合急救杂志
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care ; (6)2006.
Article in Chinese | WPRIM | ID: wpr-527338
ABSTRACT

Objective:

To observe the changes of hemeoxygenase-1 (HO-1) activity in cerebral tissue, carboxyhemoglobin (COHb) level in blood of rats during global cerebral ischemia/reperfusion (I/R) and the influence of L-tetrahydropalmatine (L-THP) on them.

Methods:

Seventy-seven Sprague-Dawley (SD) rats were randomly divided into sham-operated group (S group, n=7), I/R group (I group, n=35) and L-2THP treatment group (T group, n=35). Cerebral I/R model was reproduced in SD rats of I group and T group. HO-1 activity, cyclic GMP (cGMP) in the brain and COHb in blood were evaluated respectively at 1, 3, 12, 24, and 48 hours after global cerebral I/R and compared to those of the S group.

Results:

① HOCD*21 activity, COHb content and cGMP level in I group increased as compared with those in S group after global cerebral I/R (all P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care Year: 2006 Type: Article