Effect of hypoxia on persistent sodium current in ventricular myocytes from 3-week infarcted rat heart / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-527494
ABSTRACT
AIM:
To investigate the effect of hypoxia on persistent sodium current (I_Nap ) in single ventricular myocyte isolated from acute myocardial infarction (AMI) heart of rats and to study the mechanisms of cardiac arrhythmias that occur after AMI.METHODS:
AMI model was induced by ligating the left anterior descending coronary artery in rats. The whole-cell patch clamp technique was used to record the current in epicardial myocytes in infarcted region from rats at 3 week after AMI.RESULTS:
In normoxic conditions, the current density of I_ Nap in cardiomyocytes of fake operation (FO) and AMI hearts was 0.144?0.022 pA/pF (n=9), 0.121?0.013 pA/pF (n=9,P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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