Determination of Organic Solvent Residual Volume in Fusidic Acid by Headspace Gas Chromatography / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-527534
ABSTRACT
OBJECTIVE:
To determine organic solvent residual volume in fusidic acid by headspace gas chromatography.METHODS:
The determination was performed on polyoxyl20000DM-WAX capillary,the column was subjected to tempera-ture programming,the detector temperature was250℃,the carrier gas was helium,the flow rate was7ml/min and the split ratio was1∶1.RESULTS:
The linear detective concentration ranges of acetone,methanol and ethanol were2.04~102.50?g/ml(r=0.9992),2.00~99.98?g/ml(r=0.9995)and2.04~102.34?g/ml(r=0.9995),respectively,their average recovery rates were98.7%,99.2%and101.7%,respectively with RSD at2.11%,1.98%and2.01%,respectively.CONCLUSIONS:
The method is simple,accurate,and suitable for the determination of organic solvent residual volume in fusidic acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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