Pharmacokinetics of Single Dose Intramuscularly Injected Ziprasidone Mesylate in Healthy Volunteers / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-527539
ABSTRACT
OBJECTIVE:
To study the pharmacokinetics of a single dose of intramuscularly injected ziprasidone mesylate in healthy volunteers.METHODS:
A total of10healthy volunteers were received intramuscularly single dose of ziprasidone me-sylate20mg,venous blood samples were taken at different time after intramuscular injection,the concentrations of ziprasidone in serum were determined by HPLC,and the pharmacokinetic parameters were calculated with3p97program.RESULTS:
The concentration-time curves of ziprasidone fitted to two-compartment model.The pharmacokinetic parameters were stated as follows,C max was(866.32?482.88)ng/ml;t max was(0.57?0.23)h,t 1/2ke was(2.17?1.04)h,CL was(17.0?9.00)ml/h,AUC 0~12 was(1467.94?644.80)(ng?h)/ml and ACU 0~∝ was(1603.48?722.47)(ng?h)/ml.CONCLUSIONS:
The pharmacoki-netics parameters in10healthy volunteers after intramuscular injection of20mg ziprasidone mesylate are in line with that re-ported in the literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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