The Role of Endothelial Nitric Oxide Synthase in Endothelial Cells Apoptosis Induced by TNF-? and Angiotensin II / 昆明医科大学学报
Journal of Kunming Medical University
;
(12)1990.
Article
in Chinese
| WPRIM
| ID: wpr-527748
ABSTRACT
Objective To explore the role of eNOS and NF-?B in the cultured endothelial cells apoptosis induced by TNF-? and Ang II.Methods The cultured endothelial cells were treated with TNF-? and Ang II in absence and presence of PDTC(an inhibitor of NF-?B);the mRNA of eNOS was measured by RT-PCR,the protein of eNOS and I?B? were assessed by Western-blot,the activity of NF-?B was evaluated by EMSA,and the apoptosis of cells was detected with Tunel.Results The mRNA and protein of eNOS were significantly decreased in the endothelial cells induced by TNF-? and AngII(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Kunming Medical University
Year:
1990
Type:
Article
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