Effect of Shenyankang(肾炎康) on levels of tumor necrosis factor-? and endothelin-1 in rats with mesangial proliferative glomerulonephritis / 中国中西医结合急救杂志
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
; (6)2006.
Article
in Zh
| WPRIM
| ID: wpr-527997
Responsible library:
WPRO
ABSTRACT
Objective: To investigate the mechanism of Shenyankang(肾炎康) on rats with mesangial proliferative glomerulonephritis(MsPGN).Methods: MsPGN rat model was induced by chronic(serum-sickness).Six weeks later,MsPGN rats were given 3 ml of Shenyankang oral liquor every day(Shenyankang oral liquor treated group) or 3 ml of water every day(model group).Forty-two days after(using) the drug,urine protein(UP) of 24 hours,renal function and urine level of tumor necrosis factor?(TNF?) and endothelin1(ET1) were evaluated.Pathologic changes of renal tissue were observed by microscopy.Results: Compared to the normal control group,UP of 24 hours,blood urea nitrogen(BUN), serum creatinine(SCr) and urine level of TNF? and ET1 increased significantly in model group((all P
Full text:
1
Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
Year:
2006
Type:
Article