Quantity-Effect Research of Hemostatic Effect of Reptilase for Injection in Surgical Operations / 中国药房

ABSTRACT

OBJECTIVE:To study the quantity-effect relationship of reptilase with surgical hemostasis used at different dosages perioperatively and postoperatively.METHODS:120patients undergoing urological and general operations were ran-domly divided into experimental and control group.In the experimental group reptilase was administered at the dose of2KU by iv during the operation and continuously given at the dose of1KU～2KU by iv drip or iv twice a day after the operation until bleeding stopped.In the control group reptilase was administered at the dose of1KU by iv during the operation and continu-ously given at the dose of1KU by iv drip or iv once a day after the operation until bleeding stopped.RESULTS:The bleeding volumes in experimental and control group were(141?11.2)ml and(198?12.1)ml(P