Preliminary research of hydrogen ion excretion of renal tubule in kidney transplantation / 中国医师杂志

ABSTRACT

Objective To investigation the hydrogen ion excretion of renal tubule in 26 renal transplantation patients for 10 weeks after operation.Methods The medistream urine pH,HCO_3~-,NH_4~+ and titration acid(TA) in 26 cases of renal transplant recipients were detected before and consecutively 10 weeks after renal transplantation,and the net acid content(NAC) was calculated.Results The function of renal tubule was recovered soon but unsteadily in the early stage after transplantation, and tended to be stable after 6 weeks.The levels of TA,NH_4~+ and NAC were significantly lower in 15 cases of acute rejections episodes.The levels were increased quickly in recipients with mild rejection and good therapeutic efficacy to steroids,but slowly in those with severe rejection,requirement of anti-thymic lymphocyte globulin(ATG) or resistant to steroids.Conclusion The function of hydrogen ion excretion of renal tubule may be a better parameter than serum creatinine in reflecting the renal tubule function.It will be useful in the diagnosis of acute rejection during the consecutive observation,especially in the judgement of antirejection therapy and evaluation of prognosis.