Correlation between the signal pathway IKK/NF-?B and the anti-oxidant activity in asthma rats and the modulation of Ginkgo biloba extract / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-528269
ABSTRACT
AIM:
To investigate the correlation between the signal pathway of IKK/NF-?B and the anti-oxidant activity in asthmatic rats and the modulation of Ginkgo biloba extract (Egb).METHODS:
Thirty-six male SD rats were randomly divided into three groups control group (group C), asthmatic group (group A) and Egb group(group E). Asthma in rats was established by ovalbumin (OVA) challenge methods. The mRNA of IKK? and the protein of NF-?B P65 in lung tissue were assessed by using in situ hybridization with oligonucleotide probe and immunohistochemisty, respectively.RESULTS:
The expression of IKK? mRNA and NF-?B P65 protein in group A were significantly increased when compared with group C (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2000
Type:
Article
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