Stability Study and Infrared Spectrum Analysis on Gatifloxacin for Injection in Combination with Aciclovir for Injection / 中国药房

ABSTRACT

OBJECTIVE:To study the compatible stability of gatifloxacin for injection in combination with aciclovir for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with aciclovir within 8 hours after mixing were observed and determined under room temperature(20?1)℃,respectively,and the precipitates in the mixture underwent infrared spectrum analysis.RESULTS:White flocculent precipitate was noted in the mixture within 1 hour of mixing,which was proved as a new substance by infrared spectrum analysis. CONCLUSIONS:There is incompatibility between gatifloxacin for injection and aciclovir for injection.