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Determination of Etoposide in Children with Leukemia by HPLC / 中国药房
China Pharmacy ; (12)2005.
Article in Chinese | WPRIM | ID: wpr-528345
ABSTRACT

OBJECTIVE:

To establish HPLC method for the determination of plasma etoposide level in children with leukemia.

METHODS:

The determination was performed on column Hypersil ODS. The mobile phase was water-methanol (45∶55) and the wavelength for detection was 284nm.

RESULTS:

The intraday recovery ranged from 93.56 to 96.24% with SD ranged at 1.07%~2.63%, and the inter-day recovery ranged from 92.85% to 94.26% with SD ranged at 3.55%~5.89%.

CONCLUSION:

This method is simple and sensitive, showed a good specificity, and suitable for the determination of etoposide in clinic samples.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article