Effect of Naoreqing on endotoxin-induced fever in rabbits / 中国病理生理杂志

ABSTRACT

AIM:To observe the antipyretic effect of Naoreqing(NRQ)oral solution in rabbits with endotoxin-induced fever.METHODS:The ET-induced fever model was established in rabbits.The digital thermometer was used to register rectal temperature.The endothelin content in blood plasma,and tumor necrosis factor-?(TNF?)in blood serum were determined by radioimmunoassay.The activities of tissue-type plasminogen activator(t-PA)and plasminogen activator inhibitor(PAI)in plasma were measured by the assay of chromogenic substrate.At the same time,the pathology of lung,kidney and liver were observed.RESULTS:① NRQ showed obvious antipyretic effect in the rabbits with endotoxin-induced fever(P