Event-related potential and clinical study on cognitive dysfunction of sleep apnea syndrome / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE To explore cognitive dysfunction of sleep apnea syndrome (SAS) and compare the sensitivity of different measuring methods. METHODS Odd ball auditory P300 (2t- P300), three- tone paradigm auditory P300 (3t-P300) and mini- mental status estimate (MMSE) were performed on 24 patients with SAS and 22 healthy subjects. Results of two groups were compared. RESULTS 2t- P300 of study group(341?14.5)ms, (342?13.8)ms; 2t- P300 of normal group(317?14.7)ms, (318?12.8)ms; r-dT1 of study group(327?13.0)ms,(326?14.9)ms;r-dT1 of normal group (309?11.1)ms,(309?12.0)ms; r-dT2 of study group(325?14.9)ms,(326?11.1)ms; r-dT2 of normal group(306?9.7)ms, (305?11.7)ms.Latency of P300 evoked by odd-ball and 3-tone paradigm were both statistically prolonged in SAS patients than those of normal controls. SAS patients had statistically lower MMSE scores than that of normal group but all of them were above 27. On the other hand, statistical difference of abnormal rate between 3-tone P300 and odd-ball P300 was not found in SAS patients group. CONCLUSION Cognitive function impairment was found in SAS patients both by P300 and MMSE. While P300 might be more sensitive than MMSE in detecting it, different paradigm of auditory P300 did not show difference in sensitivity.