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Determination of 2 Kinds of Components in Compound Moxifloxacin Nasal Drops by HPLC / 中国药房
China Pharmacy ; (12)2005.
Article in Chinese | WPRIM | ID: wpr-529103
ABSTRACT

OBJECTIVE:

To establish a HPLC method for a simultaneous determination of moxifloxacin hydrochloride and ephedrine hydrochloride in compound moxifloxacin nasal drops.

METHODS:

The separation was performed on VP-ODS chromatographic column with column temperature at 30℃. The mobile phase consisted of phosphate buffer solution (which contained 0.02mol?L-1 sodium dihydrogen phosphate and 0.3% triethylamine, adjust pH to 3.0 by phosphoric acid) - methanol(60∶40) with flow rate at 1.0mL?min-1, detection wavelength at 214nm and sample size at 20?L.

RESULTS:

The linear ranges of moxifloxacin hydrochloride and ephedrine hydrochloride were 0.1~0.8(r=0.999 7,n=5) and 0.125~1.000?g (r=0.999 9, n=5), respectively,and their average recoveries were 98.94% (RSD=0.89%) and 99.67%(RSD=1.26%),respectively.

CONCLUSION:

The technique is simple, rapid, accurate, and reproducible, and it can be used as the quantity control of compound moxifloxacin nasal drops.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2005 Type: Article