Expression and their clinical significance of uPA and integrin?4 in papillary thyroid cancer / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE To investigate the expression and their clinical significance of uPA (urokinase type plasminogen activator) and integrin?4 in papillary thyroid cancer. METHODS The levels of uPA and integrin?4 were determined by Immunohistochemistry technique (S-P method) in 36 specimens from patients with papillary thyroid cancer, 30 specimens from benign thyroid tumor and normal thyroid tissues adjacent to benign thyroid tumor. RESULTS The levels of uPA and integrin?4 in benign thyroid tumor were significantly higher than that in normal tissue adjacent to benign thyroid tumor (P