Bioequivalence of 2 Preparations of Alfuzosin Hydrochloride / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-529240
ABSTRACT
OBJECTIVE:
To compare the bioequivalence between alfuzosin hydrochloride sustained release tablets and the imported alfuzosin common tablets.METHODS:
20 health volunteers were assigned to receive oral single dose of 5mg sustained-release and imported tablets of alfuzosin by self crossover way,with alfuzosin concentration in serum determined by HPLC.The pharmacokinetic parameters were calculated;the statistical analysis was carried out and the bioequiavailability was evaluated.RESULTS:
The main pharmacokinetic parameters of the sustained-release and the imported tablets of alfuzosin were as followsCmax(28.92? 9.63) ?g? L-1 vs.(32.92? 10.23) ?g? L-1;tmax(2.7? 0.6) h vs.(1.4? 1.0) h;AUC0~ ∞(221.14? 59.46) ?g? h? L-1 vs.(245.68? 67.20) ?g? h? L-1;t1/2(6.68? 0.85) vs.(4.73? 1.22) h;AUC0~ 24(215.20? 49.63) vs.(226.30? 53.60) ?g? h? L-1.The relative bioavailability of alfuzosin hydrochloride sustained release tablets was(92.2? 13.2) %.CONCLUSION:
The 2 preparations of alfuzosin are bioequivalent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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