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Effect of vitamin K_3 on apoptosis induced by androgen-independent prostate cancer cell PC-3M / 中国病理生理杂志
Article in Chinese | WPRIM | ID: wpr-529273
Responsible library: WPRO
ABSTRACT

AIM:

To study the effect of vitamin K3(VK3) on the induction of apoptosis in androgen-independent prostate cancer cell PC-3M in vitro.

METHODS:

Cell viability was estimated by MTT assay.AO/EB staining was performed to detect apoptotic cells.Apoptosis and the changes of cell cycle were detected by flow cytometry.NAC was used to observe the effect of growth inhibition by VK3.RT-PCR was used to confirm the changes in gene expression.Levels of intracellular peroxides were estimated by using an oxidation-sensitive fluorescent probe DCFH-DA.

RESULTS:

PC-3M cells growth was significantly inhibited by VK3(≥60 ?mol/L,P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2000 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2000 Type: Article