Determination of 3 Kinds of Components in Compound Xueyaan Sustained Release Tablets by HPLC / 中国药房
China Pharmacy
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-529389
ABSTRACT
OBJECTIVE:
To establish HPLC method for the determination of the contents of atenolol, hydrochlorothiazide and nifedipine in xueyaan sustained release tablets.METHODS:
The determination was performed on ZORBAX SB C18 column with column temperature at 35℃ . The mobile phase consisted of 0. 01mol? L- 1 sodium dihydrogen phosphate solution- methanol- acetonitrile ( 6∶ 3∶ 1) . The UV detection wavelength was set at 272nm and the sample size was 20? L.RESULTS:
The liner ranges of atenolol, hydrochlorothiazide and nifedipine were 10~ 250? g? mL- 1 ( r=0. 999 4) , 6~ 150? g? mL- 1( r=0. 999 6) , and 5~ 125? g? mL- 1( r=0. 999 2) respectively. The average recovery rates of the three constituents were ( 98. 51? 0. 98) % ~ ( 99. 12? 0. 98) % , ( 98. 87? 1. 10) % ~ ( 99. 69? 1. 43) % , and( 98. 80? 1. 27) % ~ ( 99. 38? 1. 13) % , respectively, with RSD at 1. 00% , 1. 17% , and 1. 25% , respectively.CONCLUSION:
The established method is simple, sensitive and reproducible, and suitable for the quality control of xueyaan sustained release tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS