Role and Mechanism of Cynanchum auriculatum on Gastrointestinal Motility / 中国药房

ABSTRACT

OBJECTIVE:To study the pharmacological action and mechanism of Cynanchum auriculatum(CYA)on the gastrointestinal tract.METHODS:Using atropine sulfate to inhibit mice's intestinal propulsive activity and the effect of CYA on the intestinal propulsive activity of mice was observed.Using clipping tail stimulation method to induce functional dyspepsia model in rats and the effect of CYA on nitrogen monoxidum(NO)level in gastric mucous membrane of the model rats was observed.Using cold and bitter rhubarb lax method to induce rat spleen-deficiency diarrhea model and the effect of CYA on levels of gastrin(GAS)and motilin(MTL)in the model rats was observed.RESULTS:CYA can apparently increase the intestinal propulsive activity of mice,markedly decrease the level of NO in gastric mucous membrane of functional dyspepsia model rats,and markedly increase levels of GAS in serum and MTL in plasma of spleen-deficiency diarrhea model rats.CONCLUSION:CYA can improve intestinal propulsive activity,which might be attributed to the decreased NO level in gastric mucous membrane and the elevated levels of GAS in serum and MTL in plasma.