Experimental Studies on the Therapic Effect of sCD14 and sTNFR-P55 on the Serious Scalded Mice / 中国药房

ABSTRACT

OBJECTIVE:To study the therapic effect of soluble cluster of differentiation (sCD14) and soluble tumor necrosis factor receptor-P55(sTNFR-P55) on the inflammation,insulin resisitance and insulin secretion of serious scalded mice. METHODS: The lecels of mortality, peripheral white blood cell(WBC), Homeostasis Assessment-Insulin Resistance (HOMA-IR) and Homeostasis Assessmen-?(HOMA-?),fasting glucose, fasting lactic acid of the scalded mice treated individually by infusion with sCD14,sTNFR-P55,and both the sCD14 and sTNFR-P55, were examined compared with that of the control. RESULTS: The mortality of the scalded mice treated both by infusion with both of sCD14 and sTNFR-p55,were lower than that of the control(P