Colquhounia root tablet inhibits the expression of adhesion molecule in acute lung injury of rats / 中国病理生理杂志

ABSTRACT

AIM:To study the effects of colquhounia root tablet on the expression of adhesion molecule in acute lung injury of rats. METHODS: The rats were divided into 3 groups ALI group, colquhounia root tablet+ALI group and control group . ALI animal model was performed by treatment with oleic acid. The positive expression rates of CD11a, CD11b and CD18 in polymorphonuclear neutrophils and monocytes were analyzed by flow cytometry. ICAM-1 expression in lung tissue was determined by immunohistochemistry, histopathological examination and biological markers were measured from lung specimens.RESULTS: Colquhounia root tablet decreased the expression of CD11a, CD11b and CD18 in polymorphonuclear neutrophils and monocytes, and ICAM-1 in lung tissue (P