On Quality Criteria of Gengnianjingxin Capsules / 中国药房

ABSTRACT

OBJECTIVE:To establish the quality criteria for Gengnianjingxin capsules.METHODS:The constituents of Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae etc in Gengnianjingxin capsules were identified by TLC; the content of Paeoniflorin in Gengnianjingxin capsules was determined by HPLC. The chromatographic separation was performed on a ODS-(3)C18 column with mobile phase consisted of acetonitrile-phosphate 0.1% (16∶84) at a flow rate of 1.0mL?min-1. The detection wavelength was 230nm. RESULTS:Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae were all well-separated and clear spots were noted in TLC. The calibration curve was linear for Peoniflorin in the range of 0.256 2～1.281 0?g?mL-1(r=0.999 9), with the average recovery rate of 101.86% and RSD of 1.72%(n=5),CONCLUSION:The established criteria are suitable for the quality control of Gengnianjingxin capsules.