Preparation and Content Determination of Cholecalciferol Microcapsules / 中国药房
China Pharmacy
;
(12)1991.
Article
in Chinese
| WPRIM
| ID: wpr-529866
ABSTRACT
OBJECTIVE:
To prepare cholecalciferol(VitD3)microcapsules and establish a method for their quantitative determination.METHODS:
Microcapsules were prepared by complex coacervation method and VitD3 content was determined by HPLC.RESULTS:
The prepared microcapsules had well-distributed particle size with average particle size of(103.9?26.2)?m and encapsulation efficiency of(90.8?2.68)%.The linear range of VitD3 was 0.1~1.0 ?g?mL-1(r=0.999 3)with mean recovery rate of 98.65% and a dissolution rate of above 75% at 45 min.CONCLUSION:
VitD3 microcapsules was successfully prepared by the established method,and the established content determination method was proved to be simple and feasible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
1991
Type:
Article
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