Antipruritic Effect of Yinxieling Tablet / 中国药房

ABSTRACT

OBJECTIVE:To study the antipruritic effect of Yinxieling tablet.METHODS: To pruritus model was made using dextran-40 to induce endogenous histamine release. The latent time for the onset of scratching after giving dextran-40 in Jimpy mice and the frequency of scratching within 30 min were observed. Histamine phosphate was given by endermic injection meanwhile evans blue physiologic saline was injected to caudal vein for staining in Jimpy mice, 30 min later, blue-stain skin was cut for the measurement of size of evans blue spots. RESULTS: The latent time was significantly longer and the scratching times were significantly less in Yinxieling tablet groups(high,middle, and low doses) than in blank group, however, no significant difference was noted between Yinxieling tablet subgroups (high and middle doses) and Chlorphenamine group. The wheal area of blue-stain skin in mice's hypogastric zone was significantly less in high dose Yinxieling tablet group than in blank group, but the difference between high dose Yinxieling tablet group and Chlorphenamine group was not significant. The high dose Yinxieling tablet group was superior to Diyin tablet in latent time, frequency of scratching and wheal area. CONCLUSION: Yinxieling tablet have satisfactory antipruritic effect.