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Optimization of the Formulation of Film Coating of Metformin Hydrochloride Sustained-release Pellets in Compound Glipizde Extended-release Capsules / 中国药房
China Pharmacy ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-530166
ABSTRACT

OBJECTIVE:

To optimize the formulation of metformin hydrochloride sustained-release pellets prepared using film coating technology.

METHODS:

Taking release rate in vitro as index, the formulation of the film-coat was prelimilarily selected using one facotr sreening method and optimzed using orthogonal test. The release rate of the prepared metformin hydrochloride sustained-release pellets was determined and compared with that metformin hydrochloride pellets.

RESULTS:

The optimized formulation was as follows the film material of Eudragit NE 30D and Eudragit L 30D55 at a ratio of 10∶1 were added with 40% talcum powder and 0.25% sodium dodecyl sulfate. The release rate of the metformin hydrochloride sustained-release pellets was higher than that of metformin hydrochloride pellets.

CONCLUSION:

The metformin hydrochloride sustained-release pellets were up to the requirements of sustained release and characterized by 24h continuous drug release.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article