Clinical Efficacy of Recombined Human Keratinocyte Growth Factor Variant for Alkali Burn in Rabbit / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-530170
ABSTRACT
OBJECTIVE:
To investigate the effect of recombined human keratinocyte growth factor variant (K102) on corneal alkali burn in rabbit.METHODS:
60 New Zealand rabbits were randomized to 5 groups. Corneal alkali burn models were made and in the left eyes of the rabbits with 1 mol?L-1 NaOH solution. Then the trial groups (groups A, B and C) were treated with 0.5, 0.25, 0.125 mg?mL-1 K102 eye drops, respectively; group D (positive control group) with bFGF eye drops, and group E (negative control group) with solvent of K102 eye drops. The rate of corneal reepithelialization and the area of neovascularization (CNV) were observed under microscope.RESULTS:
Within 24 h, the corneal epithelium growth rate in the trial groups (A, B and C) were 1.52, 1.57 and 1.46 mm2?h-1, respectively, which were significantly different as compared with negative control group (0.98 mm2?h-1) (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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