Optimization of Technical Conditions of Alprostadil Liposome / 中国药房
China Pharmacy
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-530296
ABSTRACT
OBJECTIVE:
To optimize the technical conditions of alprostadil liposome.METHODS:
Alprostadil liposome was prepared by instillation technique,and technical conditions were optimized with particle size and entrapment efficiency as indexes.RESULTS:
The optimized technical conditions for the preparation of alprostadil liposome were the followingthe concentration of ethanol was 12.5% at a stirring speed of 600 r?min-1;the instilling time was 45 min and the pH of the buffer solution was 4.05;the size distribution of the prepared alprostadil liposome was 60~200 nm and the entrapment efficiency was 88.0%~90.5%.CONCLUSION:
The instillation method for the preparation of alprostadil liposome is simple and reliable,and the technical conditions were reasonable and feasible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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