Pathogenic Bacteria in Plateau Hospital-Acquired Pulmonary Infection and Antimicrobial Susceptibility / 中国药房

ABSTRACT

OBJECTIVE: To clarify the pathogens in plateau hospital-acquired pulmonary infection and their antimicrobial susceptibility so as to provide scientific basis for clinical first-line treatment in the rational use of antibacterial drugs. METHODS: The bacteriological culture and drug susceptibility experiment on sputum and bronchial douche fluid collected from 1 396 patients with hospital-acquired pulmonary infection in our hospital from 2004 to 2006 as well as the filed medical records were analyzed retrospectively. RESULTS: 789 positive bacteria were isolated, of which, 77.82% (614/789) were gram-negative bacilli (GNB), with Klebsiella spp showing the highest percentage, accounting for 53.91% (331/614); 21.04% (166/789) were gram-positive bacteria, with staph showing the highest percentage, accounting for 46.99% (78/789).Most of the GNB were sensitive to imipenem, sulbactam/cefoperazone, then to aminoglycosides. The susceptibility rate of Gram-positive bacteria to vancomycin was 90.36%. CONCLUSION: Gram-negative bacilli were the main hospital infection pathogens, which were sensitive to imipenem, sulbactam/cefoperazone but highly resistant to ceftazidime, which calls for attention in the clinic.