Toxicity of Compound SH Chinese Medicine / 中国药房

ABSTRACT

OBJECTIVE:To observe the acute toxic effect of Compound SH Chinese medicine on mice and its effects on the indexes of liver and kidney in rabbits.METHODS:By Bliss method,KM mice(trial group)were selected and intragastrically administered with different concentration of compound SH Chinese medicine.Then the mice were followed for 14 days with toxic reaction,death,and autopsy conditions of the mice recorded.The rabbits(control group)were fed with 3% compound SH Chinese medicine-containing animal feed,from which tissue and blood samples were taken at 35 days for observation and analysis.RESULTS:Medial lethal dose(LD50)of compound SH Chinese medicine for KM mice was 409.88 g?kg-1(95% confidence interval,350.80～478.91 g?kg-1).The trial group showed clear microscopic structure of the tissues,showing no significant differences as compared with control group.And no significant differences were between the two groups in biochemical indicators of liver and kidney.CONCLUSION:Compound SH Chinese medicine has a big safety margin,and its LD50 is 40 times that of curative dose for mice;moreover,it has no significant influence on morphology and function of organs such as heart,liver,spleen,lung,kidney etc in animals,suggesting it has no acute and subacute toxicity.