Determination of Dissolution of Warfarin Potassium Tablets by UV Spectrophotometry / 中国药房

ABSTRACT

OBJECTIVE: To establish a method for the determination of dissolution of warfarin potassium tablets. METHODS: The dissolution of warfarin potassium tablets was determined by UV spectrophotometry at a detection wavelength of 283 nm with 0.1 mol?L-1 hydrochloric acid as the solvent at a volume of 900 mL. The rotation speed was 50 r?min-1 and the sampling time was 30 min. RESULTS: The method showed a good linear relationship in the range of 5～30 ?g?mL-1(r=0.999 9). The average recovery was 100.53%(RSD=0.69%). The dissolutions of 3 batches of samples were all above 90%. CONCLUSION: The method is simple,accurate and reliable,and it can be applied for the determination the dissolution of warfarin potassium tablets.