The Protective and Therapeutic Effects of Metformin on Nonalcoholic Steatohepatitis in Rats / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-530483
ABSTRACT
OBJECTIVE:
To study protective and therapeutic effects of metformin on nonalcoholic steatohepatitis(NASH) in rats.METHODS:
40 SD rats were randomized into control,model,nicotinic acid,metformin group(n=10). The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion. At the same time,the control and model groups were fed with sodium carboxymethylcellulose,the other groups were fed with relative drug.The serum TG,TC,ALT,AST,FFA,TNF-? and liver tissue TG,TC,FFA were detected and with histologically.RESULTS:
The model group developed NASH after 3 weeks. metformin significantly reduced TG,ALT,FFA,FBG,TNF-? of the serum and TG,FFA of the liver tissue,and ameliorated hepatocellular macrovesicular steatosis(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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