Attenuation Action of Liuwei Dihuang Pill on Aristolochia Fangchi-induced Toxicity / 中国药房

ABSTRACT

OBJECTIVE: To study the attenuation action of Liuwei dihuang pill on Aristolochia Fangchi-induced toxicity through determination of the content of Aristolochia acid A in Aristolochia Fangchi. METHODS: After mixed decoction of Aristolochia Fangchi with Liuwei dihuang pill,the content of Aristolochhia acid A was determined by HPLC and the content change was observed. RESULTS: Aristolochia acid A content in Aristolochia Fangchi was markedly decreased after intervention by Liuwei dihuang pill. CONCLUSION: The attenuation action of Liuwei dihuang pill is related to the downregulation of Aristolochhia aicd A content in Aristolochia Fangchi.