Pharmacokinetics of Caffeic Acid in Rats / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-530587
ABSTRACT
OBJECTIVE:
To establish a HPLC method for the determination of serum concentration of caffeic acid in rats and which was applied to the pharmacokinetic study of caffeic acid.METHODS:
The concentrations of caffeic acid in rats were determined after intragastric (ig) administration or intravenous (iv) administration of 50 mg?kg-1 caffeic acid and the pharmacokinetic parameters of caffeic acid analyzed by Topfit 2.0.RESULTS:
The main pharmacokinetic parameters of caffeic acid after ig administration of caffeic acid were as follows Cmax (0.56?0.12) ?g?mL-1; tmax (0.18?0.04) h; t1/2 (0.67?0.12) h; ke (1.05?0.20) h-1; AUC(0~t) (0.34?0.05) ?g?h?mL-1. The main pharmacokinetic parameters of caffeic acid via iv administration were as follows t1/2 (0.45?0.05) h; ke (1.55?0.18) h-1; AUC(0~t) (9.07?2.24) ?g?h?mL-1.CONCLUSION:
Administered intragastrically, caffeic acid was characterized by rapid absorption, short elimination half life (t1/2) and low absolute bioavailability in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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