Effect of SR59230A as a ?_3 Adenoreceptor on Cardiac Function and ?_3-AR Expression in Rats with Heart Failure / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-530588
ABSTRACT
OBJECTIVE:
To evaluate the effect of ?3 Adrenoceptor (?3-AR) antagonist SR59230A(SR) on cardiac function and expression of ?3-AR in rats with heart failure.METHODS:
A total of 85 male Wistar rats were enrolled 8 were as-signed to control group, and 77 were established into heart failure model and then 20 rats that modelled successly assigned ran-domly to placebo group or SR group, with placebo group intraperitoneally injected with normal saline and SR group with SR. The echocardiogram, hemodynamics, and expression of ?3-AR in rats after 7-week treatment were followed.RESULTS:
In SR group compared with placebo group, shortening fraction, ejection fraction, left ventricular end systolic pressure, dp/dtmax and dp/dtmin were significantly higher (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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