Determination of the Content of Main Components in Lipoic Acid Sustained-release Tablets by HPLC / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-530784
ABSTRACT
OBJECTIVE:
To establish an HPLC method for the determination of lipoic acid in lipoic acid sustained-release tablets.METHODS:
HPLC was conducted on a Hypersil ODS with acetonitrile-0.05 mol?mL-1 potassium dihydrogen phosphate(45∶55,adjust pH to 2.0)as mobile phase at a flow rate of 1.0 mL?min-1.The injection volume was 10 ?L;the detection wavelength was set at 219 nm and the column temperature was 25 ℃.RESULTS:
The linear range of lipoic acid was 9.99~399.70 ?g?mL-1(r=0.999)with an average recovery rate of 99.17%(RSD=0.40%);the intra-day and inter-day RSD were all less than 2.6%.CONCLUSION:
The method is simple and accurate,and suitable for the determination of the content of lipoic acid in lipoic acid sustained-release tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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