Rapamycin inhibits HMGB1 expression and releases in RAW264.7 cells induced by lipopolysaccharides in vitro / 中国病理生理杂志

ABSTRACT

0.05).Both HMGB1 mRNA expression and HMGB1 protein level were remarkably higher in LPS treatment group than that in control group(P0.05).CONCLUSION:RPM inhibits HMGB1 expression not only by directly suppressing STAT3 activation,but also by indirectly reducing TNF-? level.