Effect of the Extract of Rhizoma Polygonati Odovati on Spleen and Thymus Gland of Aging Mice / 中国药房

ABSTRACT

OBJECTIVE:To observe the effect of different polarity of components of Rhizoma Polygonati Odovati on the spleen and thymus gland in D-galactose-induced aging-model mice so as to establish the anti-aging mechanism and anti-aging active components of Rhizoma Polygonati Odovati.METHODS:Different polarity of extracts of Rhizoma Polygonati Odovati were extracted respectively with benzin petroleum,acetic ether,dehydrated alcohol,80% ethanol,and water as extract solvents.The model mice were intragastrically administered with different polarity of components of Rhizoma Polygonati Odovati for 56 consecutive days,and the effects of each extractive on the indexes and pathological change of immune organ D-galactose-induced aging-model mice were monitored.RESULTS:Compared with each other extractive,aqueous extract of Rhizoma Polygonati Odovati can prevent the atrophy of thymus and spleen,and ameliorate the patho-constitution of spleen and thymus gland.CONCLUSION:Aqueous extract of Rhizoma Polygonati Odovati maybe the anti-aging active components in Rhizoma Polygonati Odovati,and its mechanism maybe related to its function to prevent the atrophy of immune organs and improve the immune function.